| Gene Information | |
|---|---|
| Gene Name | LERN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 620 |
| Protein Names | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat and immunoglobulin domain-containing protein 1) (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q96FE5 |
| Gene Card | LINGO1 |
| Uniprot ID | Q96FE5 |
| Pfam | PF07679; PF13306; PF13855 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients. {ECO:0000269|PubMed:14686891, ECO:0000269|PubMed:15895088, ECO:0000269|PubMed:17726113}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2ID5 (X-ray 2.70A ) 4OQT (X-ray 3.23A ) |
| DBSNP | rs9855 rs750612085 rs757077698 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q9D1T0}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9D1T0}. |
| Mouse PG classification | NA |
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