| Gene Information | |
|---|---|
| Gene Name | LERK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 205 |
| Protein Names | Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) (Tumor necrosis factor alpha-induced protein 4) (TNF alpha-induced protein 4) [Cleaved into: Ephrin-A1, secreted form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P20827 |
| Gene Card | EFNA1 |
| Uniprot ID | P20827 |
| Pfam | PF00812 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). {ECO:0000269|PubMed:17332925}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3CZU (X-ray 2.65A ) 3HEI (X-ray 2.00A ) 3MBW (X-ray 2.81A ) |
| DBSNP | rs4745 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18794797}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:18794797}.; [Ephrin-A1, secreted form]: Secreted {ECO:0000269|PubMed:18794797}. |
| Mouse PG classification | NA |
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