| Gene Information | |
|---|---|
| Gene Name | LEPR |
| Organism | Homo sapiens (Human) |
| Gene Length | 1165 |
| Protein Names | Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295) |
| Target Name | leptin receptor |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000116678 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P48357 |
| Gene Card | LEPR |
| Uniprot ID | P48357 |
| Pfam | PF06328; PF18589 |
| In ASD | no |
| Allosteric Prediction | yes (0.50038583) |
| Ortholog in Animals | Alpaca_ LEPR ( ortholog_one2one ) Dog_ LEPR ( ortholog_one2one ) GuineaPig_ LEPR ( ortholog_one2one ) Macaque_ LEPR ( ortholog_one2one ) Mouse_ Lepr ( ortholog_one2one ) Pig_ LEPR ( ortholog_one2one ) Rat_ Lepr ( ortholog_one2one ) Rabbit_ LEPR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CRLF1, IL13RA2, IL11RA, IL13RA1, CNTFR, IL2RG, CRLF2, IL31RA, IL3RA, IL6ST, IL12RB1, CSF3R, IL12RB2, GHR, CSF2RA, IL6R, IL27RA, IL23R, LIFR, OSMR, IL5RA, EBI3, PRLR |
| Tissue | dura.mater |
| Tissue Specificity | Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus, but also in skeletal muscle. Detected in fundic and antral epithelial cells of the gastric mucosa (PubMed:19159218). Isoform B and isoform A are expressed by NK cells (at protein level) (PubMed:12504075). {ECO:0000269|PubMed:12504075, ECO:0000269|PubMed:16052473, ECO:0000269|PubMed:19159218}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.1(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3V6O (X-ray 1.95A ) 6E2P (X-ray 2.83A ) |
| DBSNP | rs1137100 rs35573508 rs146442768 rs1137101 rs13306526 rs1805094 rs373154589 rs34499590 rs1303050393 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19159218}; Single-pass type I membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:19159218}.; [Isoform E]: Secreted {ECO:0000250|UniProtKB:P48356}. |
| Mouse PG classification | NA |
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