| Gene Information | |
|---|---|
| Gene Name | TIMP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 211 |
| Protein Names | Metalloproteinase inhibitor 3 (Protein MIG-5) (Tissue inhibitor of metalloproteinases 3) (TIMP-3) |
| Target Name | metalloproteinase inhibitor 3 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000100234 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P35625 |
| Gene Card | TIMP3 |
| Uniprot ID | P35625 |
| Pfam | PF00965 |
| In ASD | no |
| Allosteric Prediction | yes (0.70384007) |
| Ortholog in Animals | Alpaca_ TIMP3 ( ortholog_one2one ) Alpaca_ TIMP3 ( ortholog_one2many ) Dog_ TIMP3 ( ortholog_one2one ) GuineaPig_ TIMP3 ( ortholog_one2one ) Macaque_ TIMP3 ( ortholog_one2one ) Mouse_ Timp3 ( ortholog_one2one ) Pig_ TIMP3 ( ortholog_one2one ) Rat_ Timp3 ( ortholog_one2one ) Rabbit_ TIMP3 ( ortholog_one2one ) |
| Ohnologs | TIMP1, TIMP2, TIMP4 |
| Paralogs | TIMP1, TIMP2, TIMP4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3CKI (X-ray 2.30A ) |
| DBSNP | rs137853300 rs137853301 rs137853299 rs137853298 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix. |
| Mouse PG classification | NA |
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