| Gene Information | |
|---|---|
| Gene Name | LEP |
| Organism | Homo sapiens (Human) |
| Gene Length | 167 |
| Protein Names | Leptin (Obese protein) (Obesity factor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000174697 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P41159 |
| Gene Card | LEP |
| Uniprot ID | P41159 |
| Pfam | PF02024 |
| In ASD | no |
| Allosteric Prediction | yes (0.880874857) |
| Ortholog in Animals | Alpaca_ LEP ( ortholog_one2one ) Dog_ LEP ( ortholog_one2one ) GuineaPig_ LEP ( ortholog_one2one ) Macaque_ LEP ( ortholog_one2one ) Mouse_ Lep ( ortholog_one2one ) Pig_ LEP ( ortholog_one2one ) Rat_ Lep ( ortholog_one2one ) Rabbit_ LEP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | adipose.tissue, breast, subcutaneous.adipose.tissue |
| Tissue Specificity | Adipose tissue is the main source of leptin. It is also produced by other peripheral tissues such as the skeletal muscle (PubMed:7789654, PubMed:16052473, PubMed:12448771). Expressed by intercalated and striated tracts of submandibular and parotid salivary gland intralobular ducts (PubMed:12448771). Detected by fundic epithelium of the gastric mucosa (PubMed:10896907). Secreted into blood and gastric juice (PubMed:10896907). {ECO:0000269|PubMed:10896907, ECO:0000269|PubMed:12448771, ECO:0000269|PubMed:16052473, ECO:0000269|PubMed:7789654}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1AX8 (X-ray 2.40A ) |
| DBSNP | rs17151919 rs724159998 rs104894023 rs1800564 |
| Subcellular location [CC] | Secreted {ECO:0000305|PubMed:25232147}. |
| Mouse PG classification | HPG |
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