| Gene Information | |
|---|---|
| Gene Name | LEMD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 503 |
| Protein Names | LEM domain-containing protein 2 (hLEM2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000161904 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8NC56 |
| Gene Card | LEMD2 |
| Uniprot ID | Q8NC56 |
| Pfam | PF03020; PF09402 |
| In ASD | no |
| Allosteric Prediction | no (-0.925231616) |
| Ortholog in Animals | Alpaca_ LEMD2 ( ortholog_one2one ) Dog_ LEMD2 ( ortholog_one2one ) GuineaPig_ LEMD2 ( ortholog_one2one ) Macaque_ LEMD2 ( ortholog_one2one ) Mouse_ Lemd2 ( ortholog_one2one ) Pig_ LEMD2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ANKLE1, LEMD3 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, including bone marrow, brain, kidney, colon, skeletal muscle, thymus, testis and uterus. {ECO:0000269|PubMed:16339967}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs878852983 |
| Subcellular location [CC] | Nucleus inner membrane {ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17097643, ECO:0000269|PubMed:28242692, ECO:0000269|PubMed:30905398, ECO:0000269|PubMed:32494070}; Multi-pass membrane protein {ECO:0000269|PubMed:16339967}. Nucleus envelope {ECO:0000269|PubMed:28242692}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:32494070}. Note=Lamina-associated protein residing in the inner nuclear membrane (INM) of the nuclear envelope (NE) (PubMed:16339967). The localization to the INM is dependent on LMNA (PubMed:16339967). Evenly distributed around the NE during interphase (PubMed:16339967). During metaphase, found in a reticular network (PubMed:28242692). Recruited to the reforming NE on chromatin disks in early anaphase (PubMed:28242692). In late anaphase, concentrates at the NE core proximal to spindle microtubules, and then broadening to a distributed nuclear rim pattern (PubMed:28242692, PubMed:32494070). {ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:28242692, ECO:0000269|PubMed:32494070}. |
| Mouse PG classification | NA |
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