| Gene Information | |
|---|---|
| Gene Name | LEM6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 798 |
| Protein Names | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UBK2 |
| Gene Card | PPARGC1A |
| Uniprot ID | Q9UBK2 |
| Pfam | PF00076 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects. {ECO:0000269|PubMed:10585775, ECO:0000269|PubMed:10643692, ECO:0000269|PubMed:10713165}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1XB7 (X-ray 2.50A ) 3B1M (X-ray 1.60A ) 3CS8 (X-ray 2.30A ) 3D24 (X-ray 2.11A ) 3U9Q (X-ray 1.52A ) 3V9T (X-ray 1.65A ) 3V9V (X-ray 1.60A ) 4QJR (X-ray 2.40A ) 4QK4 (X-ray 2.81A ) 5Q0I (X-ray 1.70A ) 5TWO (X-ray 1.93A ) 5UNJ (X-ray 1.96A ) 5Z5S (X-ray 1.80A ) 5Z6S (X-ray 1.80A ) 6AD9 (X-ray 2.20A ) 6FZF (X-ray 1.95A ) 6FZP (X-ray 2.30A ) 6IZM (X-ray 1.80A ) 6IZN (X-ray 1.75A ) 6K0T (X-ray 1.84A ) 6KXX (X-ray 1.95A ) 6KXY (X-ray 2.00A ) 6LN4 (X-ray 2.61A ) 6MS7 (X-ray 1.43A ) 6NWK (X-ray 1.65A ) 6NWL (X-ray 1.59A ) 6T1V (X-ray 2.21A ) 6W9K (X-ray 1.60A ) 6W9L (X-ray 1.45A ) 7E2E (X-ray 2.70A ) 7KHT (X-ray 2.50A ) |
| DBSNP | rs8192678 rs3736265 |
| Subcellular location [CC] | [Isoform 1]: Nucleus {ECO:0000269|PubMed:10713165}. Nucleus, PML body {ECO:0000250|UniProtKB:O70343}.; [Isoform B4]: Nucleus {ECO:0000269|PubMed:22589246}.; [Isoform B4-8a]: Cytoplasm {ECO:0000269|PubMed:22589246}. Nucleus {ECO:0000269|PubMed:22589246}.; [Isoform B5]: Nucleus {ECO:0000269|PubMed:22589246}. Nucleus, PML body {ECO:0000269|PubMed:22589246}.; [Isoform 9]: Nucleus {ECO:0000269|PubMed:22009745}. |
| Mouse PG classification | NA |
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