| Gene Information | |
|---|---|
| Gene Name | LDHB |
| Organism | Homo sapiens (Human) |
| Gene Length | 334 |
| Protein Names | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) |
| Target Name | l-lactate dehydrogenase b chain |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000111716 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P07195 |
| Gene Card | LDHB |
| Uniprot ID | P07195 |
| Pfam | PF02866; PF00056 |
| In ASD | yes |
| Allosteric Prediction | yes (0.907743234) |
| Ortholog in Animals | GuineaPig_ LDHB ( ortholog_one2one ) Mouse_ Ldhb ( ortholog_one2one ) Rat_ Ldhb ( ortholog_one2one ) |
| Ohnologs | LDHA, LDHC |
| Paralogs | LDHAL6B, LDHC, LDHA, MDH2, LDHAL6A |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in aerobic tissues such as cardiac muscle. {ECO:0000305|PubMed:11276087}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1I0Z (X-ray 2.10A ) 1T2F (X-ray 3.00A ) 7DBJ (X-ray 1.55A ) 7DBK (X-ray 1.80A ) |
| DBSNP | rs118203897 rs777954556 rs118203896 rs118203895 rs7966339 rs267607212 |
| Subcellular location [CC] | Cytoplasm. Mitochondrion inner membrane {ECO:0000269|PubMed:27618187}; Peripheral membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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