| Gene Information | |
|---|---|
| Gene Name | LDHA |
| Organism | Homo sapiens (Human) |
| Gene Length | 332 |
| Protein Names | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) |
| Target Name | ldha messenger rna |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000134333 ) 3 ( ENSG00000288299 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P00338 |
| Gene Card | LDHA |
| Uniprot ID | P00338 |
| Pfam | PF02866; PF00056 |
| In ASD | yes |
| Allosteric Prediction | yes (1.538801624) |
| Ortholog in Animals | Alpaca_ LDHA ( ortholog_one2one ) GuineaPig_ LDHA ( ortholog_one2one ) Mouse_ Ldha ( ortholog_one2one ) Pig_ LDHA ( ortholog_one2one ) |
| Ohnologs | LDHB |
| Paralogs | LDHB, LDHAL6B, LDHC, MDH2, LDHAL6A |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in anaerobic tissues such as skeletal muscle and liver. {ECO:0000305|PubMed:11276087}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1I10 (X-ray 2.30A ) 4AJP (X-ray 2.38A ) 4JNK (X-ray 1.90A ) 4L4R (X-ray 2.10A ) 4L4S (X-ray 2.90A ) 4M49 (X-ray 2.05A ) 4OJN (X-ray 2.40A ) 4OKN (X-ray 2.10A ) 4QO7 (X-ray 2.14A ) 4QO8 (X-ray 2.00A ) 4QSM (X-ray 3.00A ) 4QT0 (X-ray 3.20A ) 4R68 (X-ray 2.11A ) 4R69 (X-ray 3.19A ) 4RLS (X-ray 1.91A ) 4ZVV (X-ray 2.20A ) 5IXS (X-ray 2.05A ) 5IXY (X-ray 3.00A ) 5W8H (X-ray 1.80A ) 5W8I (X-ray 1.95A ) 5W8J (X-ray 1.55A ) 5W8K (X-ray 1.60A ) 5W8L (X-ray 1.95A ) 5ZJD (X-ray 2.39A ) 5ZJE (X-ray 2.93A ) 5ZJF (X-ray 2.60A ) 6BAD (X-ray 2.10A ) 6BAG (X-ray 2.40A ) 6BAX (X-ray 2.05A ) 6BAZ (X-ray 2.70A ) 6BB0 (X-ray 1.95A ) 6BB1 (X-ray 2.30A ) 6BB2 (X-ray 2.47A ) 6BB3 (X-ray 2.40A ) 6MV8 (X-ray 1.95A ) 6MVA (X-ray 2.02A ) 6Q0D (X-ray 2.05A ) 6Q13 (X-ray 2.00A ) 6SBU (X-ray 2.91A ) 6SBV (X-ray 2.60A ) 6ZZR (X-ray 2.65A ) 7M2N (X-ray 2.50A ) |
| DBSNP | rs748436361 rs200093825 |
| Subcellular location [CC] | Cytoplasm. |
| Mouse PG classification | LPG |
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