Gene Information
Gene NameMPEG1
OrganismHomo sapiens (Human)
Gene Length716
Protein NamesMacrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) (Perforin-2) (P-2)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000197629 )
Evolutionary StageEumetazoa
AlphaFoldDBQ2M385
Gene CardMPEG1
Uniprot IDQ2M385
PfamPF01823
In ASDno
Allosteric Predictionno (-0.25855433)
Ortholog in AnimalsAlpaca_ MPEG1 ( ortholog_one2one )
GuineaPig_ MPEG1 ( ortholog_one2one )
Macaque_ MPEG1 ( ortholog_one2one )
Mouse_ Pfpl ( ortholog_one2many )
Mouse_ Mpeg1 ( ortholog_one2many )
Pig_ MPEG1 ( ortholog_one2one )
Rat_ Mpeg1 ( ortholog_one2many )
Rat_ Pfpl ( ortholog_one2many )
Rabbit_ MPEG1 ( ortholog_one2one )
OhnologsNA
ParalogsNA
Tissuespleen
Tissue SpecificityExpressed constitutively in a variety of cell types including macrophages, natural killer cells, neutrophils, keratinocytes and monocytes (PubMed:26402460, PubMed:28705375, PubMed:7888681). In skin, expressed in both hematopoietic and non-hematopoietic cells with expression detected in a variety of cell types including keratinocytes, fibroblasts and endothelial cells (PubMed:30609079). {ECO:0000269|PubMed:26402460, ECO:0000269|PubMed:28705375, ECO:0000269|PubMed:30609079, ECO:0000269|PubMed:7888681}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6U23  (EM  3.49A  )  6U2J  (EM  2.37A  )  6U2K  (EM  2.93A  )  6U2L  (EM  2.83A  )  6U2W  (EM  3.63A  ) 
DBSNP rs143527301  rs11229878  rs200420254  rs544864  rs7926933  rs17153442 
Subcellular location [CC][Isoform 1]: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:28705375};
Single-pass type I membrane protein {ECO:0000255}. Note=Bacterial infection induces translocation of the cytoplasmic vesicles to bacterium-containing phagocytic vesicles and fusing of the vesicles. {ECO:0000269|PubMed:28705375}.;
[Isoform 2]: Secreted {ECO:0000269|PubMed:28705375}.
Mouse PG classificationNA
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