| Gene Information | |
|---|---|
| Gene Name | LDAF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 161 |
| Protein Names | Lipid droplet assembly factor 1 (Promethin) (Transmembrane protein 159) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000011638 ) 3 ( ENSG00000283997 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q96B96 |
| Gene Card | LDAF1 |
| Uniprot ID | Q96B96 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | Alpaca_ LDAF1 ( ortholog_one2one ) GuineaPig_ LDAF1 ( ortholog_one2one ) Macaque_ LDAF1 ( ortholog_one2one ) Mouse_ Tmem159 ( ortholog_one2one ) Pig_ LDAF1 ( ortholog_one2one ) Rat_ Tmem159 ( ortholog_one2one ) Rabbit_ LDAF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in the heart and skeletal muscle. Expressed at low levels in kidney, small intestine, lung and liver. {ECO:0000269|PubMed:15589683}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35345508 rs1046480 rs1063087 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:30901948, ECO:0000269|PubMed:31708432}; Multi-pass membrane protein {ECO:0000255}. Lipid droplet {ECO:0000269|PubMed:30901948, ECO:0000269|PubMed:31708432}. Note=Co-localizes with BSCL2/seipin in the ER, upon LD formation dissociates from BSCL2/seipin and relocalizes to LD surfaces during LD maturation. {ECO:0000269|PubMed:31708432}. |
| Mouse PG classification | NA |
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