| Gene Information | |
|---|---|
| Gene Name | LCP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 627 |
| Protein Names | Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000136167 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P13796 |
| Gene Card | LCP1 |
| Uniprot ID | P13796 |
| Pfam | PF00307; PF13499 |
| In ASD | no |
| Allosteric Prediction | no (-0.216502006) |
| Ortholog in Animals | Alpaca_ LCP1 ( ortholog_one2one ) Dog_ LCP1 ( ortholog_one2one ) GuineaPig_ LCP1 ( ortholog_one2one ) Macaque_ LCP1 ( ortholog_one2one ) Mouse_ Lcp1 ( ortholog_one2one ) Pig_ LCP1 ( ortholog_one2one ) Rat_ Lcp1 ( ortholog_one2one ) Rabbit_ LCP1 ( ortholog_one2one ) |
| Ohnologs | PLS3, PLS1 |
| Paralogs | PLS3, PLS1 |
| Tissue | NA |
| Tissue Specificity | Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells. {ECO:0000269|PubMed:3261603}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2D85 (NMR - ) 5JOJ (NMR - ) 5JOL (NMR - ) 6VEC (EM 3.90A ) |
| DBSNP | rs4941543 rs17067725 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16636079}. Cell junction {ECO:0000269|PubMed:17294403}. Cell projection {ECO:0000269|PubMed:16636079}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q61233, ECO:0000269|PubMed:16636079}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q61233}; Cytoplasmic side {ECO:0000250|UniProtKB:Q61233}. Note=Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Associated with the actin cytoskeleton at membrane ruffles. Relocalizes to actin-rich cell projections upon serine phosphorylation (PubMed:16636079). {ECO:0000250|UniProtKB:Q61233, ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403}. |
| Mouse PG classification | NA |
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