| Gene Information | |
|---|---|
| Gene Name | NCR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 304 |
| Protein Names | Natural cytotoxicity triggering receptor 1 (Lymphocyte antigen 94 homolog) (NK cell-activating receptor) (Natural killer cell p46-related protein) (NK-p46) (NKp46) (hNKp46) (CD antigen CD335) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000189430 ) 3 ( ENSG00000273535 ) 3 ( ENSG00000275156 ) 3 ( ENSG00000275521 ) 3 ( ENSG00000275637 ) 3 ( ENSG00000276450 ) 3 ( ENSG00000277334 ) 3 ( ENSG00000277442 ) 3 ( ENSG00000278025 ) 3 ( ENSG00000278362 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O76036 |
| Gene Card | NCR1 |
| Uniprot ID | O76036 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.071689683) |
| Ortholog in Animals | Alpaca_ NCR1 ( ortholog_one2many ) Dog_ NCR1 ( ortholog_one2one ) GuineaPig_ NCR1 ( ortholog_one2one ) Macaque_ NCR1 ( ortholog_one2one ) Mouse_ Ncr1 ( ortholog_one2one ) Pig_ NCR1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LILRB2, LILRB5, LILRA2, LILRA4, LILRA6, LILRA5, LILRB4, LILRB1, LILRA1, LILRB3, KIR2DL3, KIR3DL3, KIR3DL2, KIR3DL1, KIR2DS4, KIR2DL4, FCAR, KIR2DL1, GP6, IGSF1, OSCAR, TARM1, VSTM1, LAIR2, A1BG |
| Tissue | NA |
| Tissue Specificity | Selectively expressed by both resting and activated NK cells. {ECO:0000269|PubMed:9730896}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1OLL (X-ray 1.93A ) 1P6F (X-ray 2.20A ) 6IAP (X-ray 2.90A ) |
| DBSNP | rs2278428 |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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