| Gene Information | |
|---|---|
| Gene Name | LCK |
| Organism | Homo sapiens (Human) |
| Gene Length | 509 |
| Protein Names | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) |
| Target Name | lck tyrosine protein kinase |
| Target Type | Successful target |
| Gene Age | 424 ( ENSG00000182866 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P06239 |
| Gene Card | LCK |
| Uniprot ID | P06239 |
| Pfam | PF07714; PF00017; PF00018 |
| In ASD | yes |
| Allosteric Prediction | yes (1.898792196) |
| Ortholog in Animals | Alpaca_ LCK ( ortholog_one2one ) Dog_ LCK ( ortholog_one2one ) GuineaPig_ LCK ( ortholog_one2one ) Macaque_ LCK ( ortholog_one2one ) Mouse_ Lck ( ortholog_one2one ) Pig_ LCK ( ortholog_one2one ) Rat_ Lck ( ortholog_one2one ) Rabbit_ LCK ( ortholog_one2one ) |
| Ohnologs | FYN, HCK, FRK, BLK, YES1, SRC |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | lung, spleen, whole.blood |
| Tissue Specificity | Expressed specifically in lymphoid cells. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001341(Rat);0.014815(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1BHF (X-ray 1.80A ) 1BHH (X-ray 1.90A ) 1CWD (X-ray 2.25A ) 1CWE (X-ray 2.30A ) 1FBZ (X-ray 2.40A ) 1H92 (NMR - ) 1IJR (X-ray 2.20A ) 1KIK (NMR - ) 1LCJ (X-ray 1.80A ) 1LCK (X-ray 2.50A ) 1LKK (X-ray 1.00A ) 1LKL (X-ray 1.80A ) 1Q68 (NMR - ) 1Q69 (NMR - ) 1QPC (X-ray 1.60A ) 1QPD (X-ray 2.00A ) 1QPE (X-ray 2.00A ) 1QPJ (X-ray 2.20A ) 1X27 (X-ray 2.70A ) 2IIM (X-ray 1.00A ) 2OF2 (X-ray 2.00A ) 2OF4 (X-ray 2.70A ) 2OFU (X-ray 2.00A ) 2OFV (X-ray 2.00A ) 2OG8 (X-ray 2.30A ) 2PL0 (X-ray 2.80A ) 2ZM1 (X-ray 2.10A ) 2ZM4 (X-ray 2.70A ) 2ZYB (X-ray 2.55A ) 3AC1 (X-ray 1.99A ) 3AC2 (X-ray 2.10A ) 3AC3 (X-ray 2.55A ) 3AC4 (X-ray 2.70A ) 3AC5 (X-ray 2.50A ) 3AC8 (X-ray 2.30A ) 3ACJ (X-ray 2.20A ) 3ACK (X-ray 2.60A ) 3AD4 (X-ray 2.20A ) 3AD5 (X-ray 2.00A ) 3AD6 (X-ray 2.15A ) 3B2W (X-ray 2.30A ) 3BRH (X-ray 2.20A ) 3BYM (X-ray 2.00A ) 3BYO (X-ray 2.00A ) 3BYS (X-ray 2.20A ) 3BYU (X-ray 2.30A ) 3KMM (X-ray 2.80A ) 3KXZ (X-ray 2.37A ) 3LCK (X-ray 1.70A ) 3MPM (X-ray 1.95A ) 4C3F (X-ray 1.72A ) 4D8K (X-ray 2.36A ) 5MTM (X-ray 2.40A ) 5MTN (X-ray 2.85A ) 6H6A (X-ray 2.00A ) 6PDJ (X-ray 1.81A ) |
| DBSNP | rs11567841 rs587777335 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12218089, ECO:0000269|PubMed:22034844}; Lipid-anchor {ECO:0000269|PubMed:12218089, ECO:0000269|PubMed:22034844}; Cytoplasmic side {ECO:0000269|PubMed:12218089, ECO:0000269|PubMed:22034844}. Cytoplasm, cytosol {ECO:0000269|PubMed:12218089, ECO:0000269|PubMed:22034844}. Note=Present in lipid rafts in an inactive form. {ECO:0000269|PubMed:12218089}. |
| Mouse PG classification | LPG |
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