| Gene Information | |
|---|---|
| Gene Name | LCB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 473 |
| Protein Names | Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O15269 |
| Gene Card | SPTLC1 |
| Uniprot ID | O15269 |
| Pfam | PF00155 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Not detected in small intestine. {ECO:0000269|PubMed:17023427}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6M4N (EM 3.80A ) 6M4O (EM 3.40A ) 7CQI (EM 3.20A ) 7CQK (EM 3.30A ) 7K0I (EM 3.30A ) 7K0J (EM 3.10A ) 7K0K (EM 2.60A ) 7K0L (EM 3.40A ) 7K0M (EM 2.90A ) 7K0N (EM 3.10A ) 7K0O (EM 3.10A ) 7K0P (EM 3.10A ) 7K0Q (EM 3.30A ) |
| DBSNP | rs119482082 rs119482081 rs119482083 rs45461899 rs542876370 rs768841574 rs267607087 rs267607087 rs267607088 rs119482084 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O35704}; Single-pass membrane protein {ECO:0000250|UniProtKB:O35704}. |
| Mouse PG classification | NA |
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