| Gene Information | |
|---|---|
| Gene Name | LBR |
| Organism | Homo sapiens (Human) |
| Gene Length | 615 |
| Protein Names | Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000143815 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14739 |
| Gene Card | LBR |
| Uniprot ID | Q14739 |
| Pfam | PF01222; PF09465 |
| In ASD | no |
| Allosteric Prediction | yes (0.282406749) |
| Ortholog in Animals | Alpaca_ LBR ( ortholog_one2one ) Dog_ LBR ( ortholog_one2one ) Macaque_ LBR ( ortholog_one2one ) Mouse_ Lbr ( ortholog_one2one ) Pig_ LBR ( ortholog_one2one ) Rat_ AABR07021955.1 ( ortholog_one2one ) Rabbit_ LBR ( ortholog_one2one ) |
| Ohnologs | TM7SF2, DHCR7 |
| Paralogs | TM7SF2, DHCR7 |
| Tissue | NA |
| Tissue Specificity | Expressed in the bone marrow, liver, heart, adrenal gland, lung, placenta and uterus (PubMed:16784888). Expressed in osteoclasts and osteoblast-like cells (PubMed:21327084). {ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.06386(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DIG (NMR - ) |
| DBSNP | rs869312905 rs137852605 rs2230419 rs2230420 rs2275601 rs200180113 rs587777171 rs374343844 rs137852606 rs587777172 rs573510559 |
| Subcellular location [CC] | Nucleus inner membrane {ECO:0000269|PubMed:8157662}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21327084}. Cytoplasm {ECO:0000269|PubMed:21327084}. Nucleus {ECO:0000269|PubMed:21327084}. Note=Nucleus; nuclear rim. {ECO:0000269|PubMed:21327084}. |
| Mouse PG classification | NA |
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