Gene Information
Gene NameLBC
OrganismHomo sapiens (Human)
Gene Length2813
Protein NamesA-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBNA
Gene CardAKAP13
Uniprot IDQ12802
PfamPF17838; PF00621; PF10522
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityDetected in mammary gland (PubMed:9627117). Detected in heart (at protein level) (PubMed:11546812). Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle. {ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Pharmacological Animal Models0.000730(Chimpanzee);NULL(Mouse);0.002101(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2DRN  (NMR  -  )  2LG1  (NMR  -  )  4D0N  (X-ray  2.10A  )  4D0O  (X-ray  2.75A  )  6BCA  (X-ray  2.00A  ) 
DBSNP rs2061821  rs2061822  rs34434221  rs2061824  rs745191  rs7177107  rs4075256  rs4075254  rs4843074  rs4843075  rs7162168  rs35079107  rs2241268  rs2614668 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:9891067}. Cytoplasm {ECO:0000269|PubMed:9627117}. Cytoplasm, cell cortex {ECO:0000269|PubMed:11546812}. Nucleus {ECO:0000269|PubMed:9627117}. Membrane {ECO:0000269|PubMed:11696353, ECO:0000269|PubMed:9891067};
Peripheral membrane protein {ECO:0000269|PubMed:11696353, ECO:0000305|PubMed:9891067}. Note=Colocalizes with the actin cytoskeleton at the cell cortex. {ECO:0000269|PubMed:11546812}.
Mouse PG classificationNA
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