| Gene Information | |
|---|---|
| Gene Name | LATS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1130 |
| Protein Names | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) |
| Target Name | serine/threonine-protein kinase lats1 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000131023 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95835 |
| Gene Card | LATS1 |
| Uniprot ID | O95835 |
| Pfam | PF00069; PF00627 |
| In ASD | no |
| Allosteric Prediction | no (-0.392786514) |
| Ortholog in Animals | Alpaca_ LATS1 ( ortholog_one2one ) Dog_ LATS1 ( ortholog_one2one ) GuineaPig_ LATS1 ( ortholog_one2one ) Macaque_ LATS1 ( ortholog_one2one ) Mouse_ Lats1 ( ortholog_one2one ) Pig_ LATS1 ( ortholog_one2one ) Rat_ Lats1 ( ortholog_one2one ) Rabbit_ LATS1 ( ortholog_one2one ) |
| Ohnologs | LATS2 |
| Paralogs | STK32B, MAST3, STK32A, MAST2, LATS2, SGK1, MAST4, SGK2, SGK3, STK32C, MAST1, DMPK, MASTL |
| Tissue | NA |
| Tissue Specificity | Expressed in all adult tissues examined except for lung and kidney. {ECO:0000269|PubMed:10518011}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002043(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4ZRK (X-ray 2.32A ) 5B5W (X-ray 2.96A ) 5BRK (X-ray 2.30A ) 7LWH (X-ray 1.61A ) |
| DBSNP | rs55945045 rs34793526 rs56149740 rs56348064 rs55874734 rs35163691 rs1390558952 rs56412005 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10518011}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10518011}. Midbody {ECO:0000269|PubMed:10518011}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:10518011}. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis. {ECO:0000269|PubMed:10518011}. |
| Mouse PG classification | NA |
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