| Gene Information | |
|---|---|
| Gene Name | LAT4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 569 |
| Protein Names | Large neutral amino acids transporter small subunit 4 (L-type amino acid transporter 4) (Solute carrier family 43 member 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8N370 |
| Gene Card | SLC43A2 |
| Uniprot ID | Q8N370 |
| Pfam | PF07690 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in several tissues with higher expression in placenta, kidney and peripheral blood leukocytes (PubMed:15659399). In the kidney, is detected in epithelial cells of the distal tubule and collecting duct (PubMed:15659399). In the intestine, is expressed mainly in crypt cells of the intestinal microvilli and epithelial cells in the base of the villus (PubMed:15659399). {ECO:0000269|PubMed:15659399}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:30379325}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8CGA3}. Note=Located at the basolateral membrane in the small intestine enterocytes, kidney proximal tubule, thick ascending limb and, to a minor extent, of distal convoluted tubule epithelial cells. {ECO:0000250|UniProtKB:Q8CGA3}. |
| Mouse PG classification | NA |
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