Gene Information
Gene NameLAT1
OrganismHomo sapiens (Human)
Gene Length507
Protein NamesLarge neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ01650
Gene CardSLC7A5
Uniprot IDQ01650
PfamPF13520
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityDetected in placenta, in the syncytiotrophoblast layer (at protein level) (PubMed:11389679). Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2. {ECO:0000269|PubMed:10049700, ECO:0000269|PubMed:10072483, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12824232, ECO:0000269|PubMed:1597461, ECO:0000269|PubMed:16027961, ECO:0000269|PubMed:16496379}.
Pharmacological Animal Models0.000730(Chimpanzee);0.001000(Mouse);0.010990(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6IRS  (EM  3.30A  )  6IRT  (EM  3.50A  )  6JMQ  (EM  3.31A  )  7DSK  (EM  2.90A  )  7DSL  (EM  2.90A  )  7DSN  (EM  3.10A  )  7DSQ  (EM  3.40A  ) 
DBSNP rs17853937  rs1060250 
Subcellular location [CC]Apical cell membrane {ECO:0000269|PubMed:11742812};
Multi-pass membrane protein {ECO:0000269|PubMed:30867591}. Cell membrane {ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:9751058};
Multi-pass membrane protein {ECO:0000269|PubMed:30867591}. Lysosome membrane {ECO:0000269|PubMed:25998567};
Multi-pass membrane protein {ECO:0000305|PubMed:25998567}. Note=Located to the plasma membrane by SLC3A2/4F2hc (PubMed:9751058). Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812). Recruited to lysosomes by LAPTM4B (PubMed:25998567). {ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:9751058}.
Mouse PG classificationNA
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