| Gene Information | |
|---|---|
| Gene Name | LAT |
| Organism | Homo sapiens (Human) |
| Gene Length | 262 |
| Protein Names | Linker for activation of T-cells family member 1 (36 kDa phospho-tyrosine adapter protein) (pp36) (p36-38) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000213658 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | O43561 |
| Gene Card | LAT |
| Uniprot ID | O43561 |
| Pfam | PF15234 |
| In ASD | no |
| Allosteric Prediction | yes (0.040288182) |
| Ortholog in Animals | Alpaca_ LAT ( ortholog_one2one ) GuineaPig_ LAT ( ortholog_one2one ) Mouse_ Lat ( ortholog_one2one ) Pig_ LAT ( ortholog_one2one ) Rat_ Lat ( ortholog_one2one ) Rabbit_ LAT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level). {ECO:0000269|PubMed:16160011, ECO:0000269|PubMed:9489702}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001516(Rat);0.031579(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}; Single-pass type III membrane protein {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}. Note=Present in lipid rafts. |
| Mouse PG classification | NA |
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