| Gene Information | |
|---|---|
| Gene Name | LARS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 903 |
| Protein Names | Leucine--tRNA ligase, mitochondrial (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) |
| Target Name | probable leucine--trna ligase, mitochondrial |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000011376 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q15031 |
| Gene Card | LARS2 |
| Uniprot ID | Q15031 |
| Pfam | PF08264; PF00133 |
| In ASD | no |
| Allosteric Prediction | yes (0.009509306) |
| Ortholog in Animals | Alpaca_ LARS2 ( ortholog_one2one ) Dog_ LARS2 ( ortholog_one2one ) GuineaPig_ LARS2 ( ortholog_one2one ) Macaque_ LARS2 ( ortholog_one2one ) Mouse_ Lars2 ( ortholog_one2one ) Pig_ LARS2 ( ortholog_one2one ) Rat_ Lars2 ( ortholog_one2one ) Rabbit_ LARS2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VARS1, MARS2, MARS1, IARS1, VARS2, IARS2, LARS1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, but highest expression in tissues with high metabolic rates, such as skeletal muscle, heart, and kidney. {ECO:0000269|PubMed:20194621}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs879255606 rs199589947 rs398123036 rs36054230 rs9827689 |
| Subcellular location [CC] | Mitochondrion matrix {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |