| Gene Information | |
|---|---|
| Gene Name | LARS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1176 |
| Protein Names | Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000133706 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q9P2J5 |
| Gene Card | LARS1 |
| Uniprot ID | Q9P2J5 |
| Pfam | PF08264; PF00133 |
| In ASD | no |
| Allosteric Prediction | yes (0.334251128) |
| Ortholog in Animals | Alpaca_ LARS1 ( ortholog_one2one ) Dog_ LARS1 ( ortholog_one2one ) GuineaPig_ LARS1 ( ortholog_one2one ) Macaque_ LARS1 ( ortholog_one2one ) Mouse_ Lars ( ortholog_one2one ) Pig_ LARS1 ( ortholog_one2one ) Rat_ Lars1 ( ortholog_one2one ) Rabbit_ LARS1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VARS1, MARS2, MARS1, LARS2, IARS1, VARS2, IARS2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.049626(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2WFD (X-ray 3.25A ) 6KID (X-ray 3.15A ) 6KIE (X-ray 3.15A ) 6KQY (X-ray 3.30A ) 6KR7 (X-ray 4.00A ) 6LPF (X-ray 2.49A ) 6LR6 (X-ray 3.01A ) |
| DBSNP | rs112954500 rs201861847 rs10988 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. |
| Mouse PG classification | NA |
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