| Gene Information | |
|---|---|
| Gene Name | KCNT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1230 |
| Protein Names | Potassium channel subfamily T member 1 (KCa4.1) |
| Target Name | calcium-activated potassium channel kca4.1 |
| Target Type | Clinical trial target |
| Gene Age | 810 ( ENSG00000107147 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q5JUK3 |
| Gene Card | KCNT1 |
| Uniprot ID | Q5JUK3 |
| Pfam | PF03493; PF07885 |
| In ASD | no |
| Allosteric Prediction | yes (0.120350885) |
| Ortholog in Animals | Alpaca_ KCNT1 ( ortholog_one2one ) Dog_ KCNT1 ( ortholog_one2one ) GuineaPig_ KCNT1 ( ortholog_one2one ) Macaque_ KCNT1 ( ortholog_one2one ) Mouse_ Kcnt1 ( ortholog_one2one ) Pig_ KCNT1 ( ortholog_one2one ) Rat_ Kcnt1 ( ortholog_one2one ) |
| Ohnologs | KCNT2 |
| Paralogs | KCNU1, KCNT2, KCNMA1 |
| Tissue | brain, ovary, spleen, cerebellar.hemisphere, cerebellum, cerebral.cortex |
| Tissue Specificity | Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle. {ECO:0000269|PubMed:10718198}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs587777264 rs397515407 rs397515402 rs397515404 rs886041691 rs1185192267 rs370521183 rs397515406 rs797044544 rs397515405 rs397515403 rs1057519544 rs1424788778 rs758311066 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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