| Gene Information | |
|---|---|
| Gene Name | LARG |
| Organism | Homo sapiens (Human) |
| Gene Length | 1544 |
| Protein Names | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NZN5 |
| Gene Card | ARHGEF12 |
| Uniprot ID | Q9NZN5 |
| Pfam | PF00595; PF17838; PF09128; PF00621 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Isoform 2 is found in jejunum and testis. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1TXD (X-ray 2.13A ) 1X86 (X-ray 3.22A ) 2OMJ (NMR - ) 2OS6 (NMR - ) |
| DBSNP | rs2305013 |
| Subcellular location [CC] | Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}. Note=Translocated to the membrane upon stimulation. {ECO:0000305}. |
| Mouse PG classification | NA |
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