| Gene Information | |
|---|---|
| Gene Name | SORD |
| Organism | Homo sapiens (Human) |
| Gene Length | 357 |
| Protein Names | Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) ((R,R)-butanediol dehydrogenase) (EC 1.1.1.4) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Ribitol dehydrogenase) (RDH) (EC 1.1.1.56) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9) |
| Target Name | sorbitoldehydrogenase |
| Target Type | Literature-reported target |
| Gene Age | 1488 ( ENSG00000140263 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q00796 |
| Gene Card | SORD |
| Uniprot ID | Q00796 |
| Pfam | PF08240; PF00107 |
| In ASD | no |
| Allosteric Prediction | yes (0.038411525) |
| Ortholog in Animals | Alpaca_ SORD ( ortholog_one2one ) Dog_ SORD ( ortholog_one2one ) GuineaPig_ SORD ( ortholog_one2one ) Macaque_ SORD ( ortholog_one2one ) Mouse_ Sord ( ortholog_one2one ) Pig_ SORD ( ortholog_one2one ) Rat_ Sord ( ortholog_one2one ) Rabbit_ SORD ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MECR, CRYZ, RTN4IP1, PTGR2, TP53I3, CRYZL1, PTGR3, ADH6, ADH4, ADH1B, ADH1A, ADH1C, VAT1L, PTGR1, ADH5, ADH7, VAT1 |
| Tissue | NA |
| Tissue Specificity | Expressed in liver (PubMed:3365415). Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level). {ECO:0000269|PubMed:16278369, ECO:0000269|PubMed:19423711, ECO:0000269|PubMed:20372835, ECO:0000269|PubMed:3365415}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1PL6 (X-ray 2.00A ) 1PL7 (X-ray 2.20A ) 1PL8 (X-ray 1.90A ) |
| DBSNP | rs145813597 rs1042079 rs930337 rs149975952 |
| Subcellular location [CC] | Mitochondrion membrane {ECO:0000250|UniProtKB:Q64442}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64442}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q64442}. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface. {ECO:0000250|UniProtKB:Q64442}. |
| Mouse PG classification | NA |
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