| Gene Information | |
|---|---|
| Gene Name | LAP4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1630 |
| Protein Names | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q14160 |
| Gene Card | SCRIB |
| Uniprot ID | Q14160 |
| Pfam | PF13855; PF00595 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level). {ECO:0000269|PubMed:15806148}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001823(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1UJU (NMR - ) 1WHA (NMR - ) 1X5Q (NMR - ) 2W4F (X-ray 1.30A ) 4WYT (X-ray 2.60A ) 4WYU (X-ray 2.50A ) 5VWC (X-ray 1.91A ) 5VWI (X-ray 1.75A ) 5VWK (X-ray 2.35A ) 6EEY (X-ray 1.15A ) 6ESP (NMR - ) 6MS1 (X-ray 1.35A ) 6MTU (X-ray 2.14A ) 6MTV (X-ray 2.60A ) 6MYE (X-ray 1.10A ) 6MYF (X-ray 1.60A ) 6XA6 (X-ray 1.95A ) 6XA7 (X-ray 2.50A ) 6XA8 (X-ray 2.20A ) 7JO7 (X-ray 2.44A ) 7QRS (X-ray 1.77A ) 7QRT (X-ray 1.90A ) 7QS8 (X-ray 1.85A ) 7QS9 (X-ray 1.80A ) 7QSA (X-ray 2.02A ) 7QSB (X-ray 1.84A ) 7QTO (X-ray 3.50A ) 7QTP (X-ray 1.90A ) 7QTU (X-ray 2.84A ) |
| DBSNP | rs6558394 rs1302482009 rs782428100 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:28169360}; Peripheral membrane protein. Cell junction {ECO:0000269|PubMed:27380321}. Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Postsynapse {ECO:0000269|PubMed:15182672}. Presynapse {ECO:0000269|PubMed:15182672}. Note=Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. In a subset of CD4+ T-cells, colocalizes with CRTAM at the immunological synapse during the late phase of T-cell activation (By similarity). {ECO:0000250|UniProtKB:Q80U72}. |
| Mouse PG classification | NA |
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