Gene Information
Gene NameLAMP3
OrganismHomo sapiens (Human)
Gene Length416
Protein NamesLysosome-associated membrane glycoprotein 3 (LAMP-3) (Lysosomal-associated membrane protein 3) (DC-lysosome-associated membrane glycoprotein) (DC LAMP) (Protein TSC403) (CD antigen CD208)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000078081 )
Evolutionary StageVertebrata
AlphaFoldDBQ9UQV4
Gene CardLAMP3
Uniprot IDQ9UQV4
PfamPF01299
In ASDno
Allosteric Predictionno (-0.833021559)
Ortholog in AnimalsAlpaca_ LAMP3 ( ortholog_one2one )
Macaque_ LAMP3 ( ortholog_one2one )
OhnologsNA
ParalogsNA
Tissuelung
Tissue SpecificityDetected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues. {ECO:0000269|PubMed:21930964, ECO:0000269|PubMed:9721848, ECO:0000269|PubMed:9768752}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4AKM  (X-ray  2.69A  ) 
DBSNP rs17853113  rs482912 
Subcellular location [CC]Cell surface {ECO:0000269|PubMed:27329040}. Lysosome membrane {ECO:0000269|PubMed:21930964, ECO:0000269|PubMed:9768752};
Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9768752};
Single-pass type I membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:21810281};
Single-pass type I membrane protein {ECO:0000255}. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752). Detected on lysosomes in mature dendritic cells (PubMed:9768752). {ECO:0000269|PubMed:9768752}.
Mouse PG classificationNA
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