| Gene Information | |
|---|---|
| Gene Name | LAMP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 417 |
| Protein Names | Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000185896 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P11279 |
| Gene Card | LAMP1 |
| Uniprot ID | P11279 |
| Pfam | PF01299 |
| In ASD | no |
| Allosteric Prediction | no (-0.374633039) |
| Ortholog in Animals | Alpaca_ LAMP1 ( ortholog_one2one ) Dog_ LAMP1 ( ortholog_one2one ) GuineaPig_ LAMP1 ( ortholog_one2one ) Macaque_ LAMP1 ( ortholog_one2one ) Mouse_ Lamp1 ( ortholog_one2one ) Pig_ LAMP1 ( ortholog_one2one ) Rat_ Lamp1 ( ortholog_one2one ) Rabbit_ LAMP1 ( ortholog_one2one ) |
| Ohnologs | LAMP2 |
| Paralogs | LAMP2, CD68, LAMP5 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.032468(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs9577230 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:23847195}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:16176980}; Single-pass type I membrane protein {ECO:0000255}. Cytolytic granule membrane {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:24088571}; Single-pass type I membrane protein {ECO:0000255}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). {ECO:0000250|UniProtKB:P05300, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319}. |
| Mouse PG classification | NA |
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