| Gene Information | |
|---|---|
| Gene Name | HTR4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 388 |
| Protein Names | 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) |
| Target Name | 5-ht 4 receptor |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000164270 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13639 |
| Gene Card | HTR4 |
| Uniprot ID | Q13639 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.26604802) |
| Ortholog in Animals | Alpaca_ HTR4 ( ortholog_one2one ) Dog_ HTR4 ( ortholog_one2one ) GuineaPig_ HTR4 ( ortholog_one2one ) Macaque_ HTR4 ( ortholog_one2one ) Mouse_ Htr4 ( ortholog_one2one ) Pig_ HTR4 ( ortholog_one2one ) Rat_ Htr4 ( ortholog_one2one ) Rabbit_ HTR4 ( ortholog_one2one ) |
| Ohnologs | ADRA1A, HTR7, ADRA1D, DRD5 |
| Paralogs | HRH2, TAAR6, DRD4, HRH1, DRD1, GPR52, HTR1A, HTR1D, CHRM3, CHRM4, HRH3, TAAR5, TAAR1, GPR21, CHRM1, HRH4, TAAR9, CHRM5, TAAR8, DRD3, GPR84, CHRM2, GPR161, DRD5, TAAR2 |
| Tissue | NA |
| Tissue Specificity | Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle. {ECO:0000269|PubMed:15118808}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5EM9 (X-ray 1.60A ) 7XT8 (EM 3.10A ) 7XT9 (EM 3.20A ) 7XTA (EM 3.20A ) |
| DBSNP | rs199508638 rs34826744 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli. {ECO:0000250}. |
| Mouse PG classification | NA |
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