| Gene Information | |
|---|---|
| Gene Name | LAMC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1193 |
| Protein Names | Laminin subunit gamma-2 (Cell-scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Epiligrin subunit gamma) (Kalinin subunit gamma) (Kalinin/nicein/epiligrin 100 kDa subunit) (Ladsin 140 kDa subunit) (Laminin B2t chain) (Laminin-5 subunit gamma) (Large adhesive scatter factor 140 kDa subunit) (Nicein subunit gamma) |
| Target Name | laminin gamma-2 subunit |
| Target Type | Literature-reported target |
| Gene Age | 332 ( ENSG00000058085 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13753 |
| Gene Card | LAMC2 |
| Uniprot ID | Q13753 |
| Pfam | PF00052; PF00053 |
| In ASD | no |
| Allosteric Prediction | yes (0.213517066) |
| Ortholog in Animals | Alpaca_ LAMC2 ( ortholog_one2one ) Dog_ LAMC2 ( ortholog_one2one ) GuineaPig_ LAMC2 ( ortholog_one2one ) Macaque_ LAMC2 ( ortholog_one2one ) Mouse_ Lamc2 ( ortholog_one2one ) Pig_ LAMC2 ( ortholog_one2one ) Rat_ Lamc2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LAMB2, LAMC3, NTN4, LAMB1, LAMA3, LAMC1, ATRNL1, LAMA2, TMEFF2, ATRN, NTN1, NTN3, TMEFF1, LAMA1, AGRN, LAMB4, NTNG2, NTNG1, LAMA4, MEGF9, MEGF8, LAMB3, EGFLAM, LAMA5, NTN5, USH2A, HSPG2 |
| Tissue | NA |
| Tissue Specificity | The large variant is expressed only in specific epithelial cells of embryonic and neonatal tissues. In 17-week old embryo the small variant is found in cerebral cortex, lung, and distal tubes of kidney, but not in epithelia except for distal tubuli. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs12065473 rs17481405 rs11586699 rs12037099 rs2296306 rs4373715 rs2296303 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. |
| Mouse PG classification | HPG |
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