| Gene Information | |
|---|---|
| Gene Name | LAMA4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1823 |
| Protein Names | Laminin subunit alpha-4 (Laminin-14 subunit alpha) (Laminin-8 subunit alpha) (Laminin-9 subunit alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000112769 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q16363 |
| Gene Card | LAMA4 |
| Uniprot ID | Q16363 |
| Pfam | PF00053; PF02210; PF06008; PF06009 |
| In ASD | no |
| Allosteric Prediction | no (-0.280026372) |
| Ortholog in Animals | Alpaca_ LAMA4 ( ortholog_one2one ) Dog_ LAMA4 ( ortholog_one2one ) GuineaPig_ LAMA4 ( ortholog_one2one ) Macaque_ LAMA4 ( ortholog_one2one ) Mouse_ Lama4 ( ortholog_one2one ) Pig_ LAMA4 ( ortholog_one2one ) Rat_ Lama4 ( ortholog_one2one ) Rabbit_ LAMA4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LAMB2, LAMC3, NTN4, LAMB1, LAMA3, LAMC1, ATRNL1, LAMA2, TMEFF2, ATRN, NTN1, NTN3, LAMC2, TMEFF1, LAMA1, AGRN, LAMB4, NTNG2, NTNG1, MEGF9, MEGF8, LAMB3, EGFLAM, LAMA5, NTN5, USH2A, HSPG2 |
| Tissue | NA |
| Tissue Specificity | In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn tissues is observed in certain mesenchymal cells in tissues such as smooth muscle and dermis. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35349917 rs11757455 rs9400522 rs3752579 rs1050348 rs2032567 rs1050349 rs12110554 rs3734292 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. |
| Mouse PG classification | NA |
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