| Gene Information | |
|---|---|
| Gene Name | LAMA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 3122 |
| Protein Names | Laminin subunit alpha-2 (Laminin M chain) (Laminin-12 subunit alpha) (Laminin-2 subunit alpha) (Laminin-4 subunit alpha) (Merosin heavy chain) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000196569 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | NA |
| Gene Card | LAMA2 |
| Uniprot ID | P24043 |
| Pfam | PF00052; PF00053; PF00054; PF06008; PF06009; PF00055 |
| In ASD | no |
| Allosteric Prediction | no (-0.405904911) |
| Ortholog in Animals | Alpaca_ LAMA2 ( ortholog_one2one ) Dog_ LAMA2 ( ortholog_one2one ) GuineaPig_ LAMA2 ( ortholog_one2one ) Macaque_ LAMA2 ( ortholog_one2one ) Mouse_ Lama2 ( ortholog_one2one ) Rat_ Lama2 ( ortholog_one2one ) Rabbit_ LAMA2 ( ortholog_one2one ) |
| Ohnologs | LAMA1 |
| Paralogs | LAMB2, LAMC3, NTN4, LAMB1, LAMA3, LAMC1, ATRNL1, TMEFF2, ATRN, NTN1, NTN3, LAMC2, TMEFF1, LAMA1, AGRN, LAMB4, NTNG2, NTNG1, LAMA4, MEGF9, MEGF8, LAMB3, EGFLAM, LAMA5, NTN5, USH2A, HSPG2 |
| Tissue | NA |
| Tissue Specificity | Placenta, striated muscle, peripheral nerve, cardiac muscle, pancreas, lung, spleen, kidney, adrenal gland, skin, testis, meninges, choroid plexus, and some other regions of the brain; not in liver, thymus and bone. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4YEP (X-ray 1.19A ) 4YEQ (X-ray 3.20A ) |
| DBSNP | rs34626728 rs886043693 rs3778142 rs1562273395 rs121913574 rs118083923 rs3816665 rs35879899 rs117422805 rs121913573 rs35277491 rs2306942 rs35889149 rs147077184 rs4143752 rs3828736 rs34367843 rs121913570 rs2229848 rs2244008 rs886039896 rs34551216 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. |
| Mouse PG classification | NA |
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