| Gene Information | |
|---|---|
| Gene Name | LACC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 430 |
| Protein Names | Purine nucleoside phosphorylase LACC1 (EC 2.4.2.1) (Adenosine deaminase LACC1) (EC 3.5.4.4) (Fatty acid metabolism-immunity nexus) (Guanosine phosphorylase LACC1) (Laccase domain-containing protein 1) (S-methyl-5'-thioadenosine phosphorylase LACC1) (EC 2.4.2.28) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000179630 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q8IV20 |
| Gene Card | LACC1 |
| Uniprot ID | Q8IV20 |
| Pfam | PF02578 |
| In ASD | no |
| Allosteric Prediction | no (-0.567445304) |
| Ortholog in Animals | Alpaca_ LACC1 ( ortholog_one2one ) Dog_ LACC1 ( ortholog_one2one ) GuineaPig_ LACC1 ( ortholog_one2one ) Macaque_ LACC1 ( ortholog_one2one ) Mouse_ Lacc1 ( ortholog_one2one ) Pig_ LACC1 ( ortholog_one2one ) Rat_ Lacc1 ( ortholog_one2one ) Rabbit_ LACC1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, with higher expression levels in immune-related tissues such as lymph nodes and spleen (PubMed:27959965). Expressed in both intestinal and peripheral myeloid-derived cells (PubMed:28593945). {ECO:0000269|PubMed:27959965, ECO:0000269|PubMed:28593945}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3764147 rs730880295 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q8BZT9}. Nucleus {ECO:0000250|UniProtKB:Q8BZT9}. Endoplasmic reticulum {ECO:0000269|PubMed:31875558}. Peroxisome {ECO:0000269|PubMed:27478939, ECO:0000269|PubMed:27959965}. Note=Upon stimulation of the pattern-recognition receptor (PRR) NOD2, localizes to the endoplasmic reticulum. {ECO:0000269|PubMed:31875558}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |