| Gene Information | |
|---|---|
| Gene Name | KYNU |
| Organism | Homo sapiens (Human) |
| Gene Length | 465 |
| Protein Names | Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase) |
| Target Name | kynureninase |
| Target Type | Preclinical target |
| Gene Age | 544 ( ENSG00000115919 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q16719 |
| Gene Card | KYNU |
| Uniprot ID | Q16719 |
| Pfam | PF00266 |
| In ASD | no |
| Allosteric Prediction | yes (0.664891615) |
| Ortholog in Animals | Alpaca_ KYNU ( ortholog_one2one ) Dog_ KYNU ( ortholog_one2one ) GuineaPig_ KYNU ( ortholog_one2one ) Macaque_ KYNU ( ortholog_one2one ) Mouse_ Kynu ( ortholog_one2one ) Pig_ KYNU ( ortholog_one2one ) Rat_ Kynu ( ortholog_one2one ) Rabbit_ KYNU ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | placenta |
| Tissue Specificity | Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions. {ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2HZP (X-ray 2.00A ) 3E9K (X-ray 1.70A ) |
| DBSNP | rs2304705 rs606231307 rs9013 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_03017, ECO:0000269|PubMed:8706755}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |