Gene Information
Gene NameKSR1
OrganismHomo sapiens (Human)
Gene Length923
Protein NamesKinase suppressor of Ras 1 (EC 2.7.11.1)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000141068 )
Evolutionary StageVertebrata
AlphaFoldDBQ8IVT5
Gene CardKSR1
Uniprot IDQ8IVT5
PfamPF07714; PF13543; PF20406
In ASDno
Allosteric Predictionyes (0.416070484)
Ortholog in AnimalsAlpaca_ KSR1 ( ortholog_one2one )
GuineaPig_ KSR1 ( ortholog_one2one )
Macaque_ KSR1 ( ortholog_one2one )
Mouse_ Ksr1 ( ortholog_one2one )
Pig_ KSR1 ( ortholog_one2one )
Rat_ Ksr1 ( ortholog_one2one )
Rabbit_ KSR1 ( ortholog_one2one )
OhnologsKSR2
ParalogsLIMK2, RIPK1, LRRK2, TNNI3K, TESK2, KSR2, MAP3K10, RIPK2, MOS, MAP3K9, MLKL, MAP3K20, ARAF, TESK1, MAP3K13, BRAF, ILK, MAP3K11, RAF1, MAP3K12, MAP3K21, LIMK1, RIPK3
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5VYK  (X-ray  1.75A  )  7JUW  (X-ray  2.88A  )  7JUX  (X-ray  3.34A  )  7JUY  (X-ray  3.10A  )  7JUZ  (X-ray  3.21A  )  7JV0  (X-ray  3.63A  )  7JV1  (X-ray  3.62A  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:20679487}. Membrane {ECO:0000269|PubMed:20679487};
Peripheral membrane protein {ECO:0000269|PubMed:20679487}. Cell membrane {ECO:0000250|UniProtKB:Q61097};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q61097}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q61097}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20679487}. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery. {ECO:0000305|PubMed:12007434}.
Mouse PG classificationNA
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