| Gene Information | |
|---|---|
| Gene Name | ME1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 572 |
| Protein Names | NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1) |
| Target Name | nadp-dependent malic enzyme |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000065833 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P48163 |
| Gene Card | ME1 |
| Uniprot ID | P48163 |
| Pfam | PF00390; PF03949 |
| In ASD | yes |
| Allosteric Prediction | yes (1.168789848) |
| Ortholog in Animals | Alpaca_ ME1 ( ortholog_one2one ) Dog_ ME1 ( ortholog_one2one ) GuineaPig_ ME1 ( ortholog_one2one ) Macaque_ ME1 ( ortholog_one2one ) Mouse_ Me1 ( ortholog_one2one ) Pig_ ME1 ( ortholog_one2one ) Rat_ Me1 ( ortholog_one2one ) Rabbit_ ME1 ( ortholog_one2one ) |
| Ohnologs | ME2, ME3 |
| Paralogs | ME3, ME2 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues tested including liver, placenta and white adipose tissue. {ECO:0000269|PubMed:7622060, ECO:0000269|PubMed:8187880}. |
| Pharmacological Animal Models | 0.027303(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2AW5 (X-ray 2.50A ) 3WJA (X-ray 2.55A ) 7X11 (X-ray 2.07A ) 7X12 (X-ray 2.07A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:8187880}. |
| Mouse PG classification | NA |
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