| Gene Information | |
|---|---|
| Gene Name | PDCD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 288 |
| Protein Names | Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279) |
| Target Name | programmed cell death protein 1 |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000188389 ) 3 ( ENSG00000276977 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q15116 |
| Gene Card | PDCD1 |
| Uniprot ID | Q15116 |
| Pfam | PF07686 |
| In ASD | yes |
| Allosteric Prediction | yes (0.161866105) |
| Ortholog in Animals | Alpaca_ PDCD1 ( ortholog_one2one ) Dog_ PDCD1 ( ortholog_one2one ) GuineaPig_ PDCD1 ( ortholog_one2one ) Macaque_ PDCD1 ( ortholog_one2one ) Mouse_ Pdcd1 ( ortholog_one2one ) Pig_ PDCD1 ( ortholog_one2one ) Rat_ Pdcd1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | lymph.node |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2M2D (NMR - ) 3RRQ (X-ray 2.10A ) 4ZQK (X-ray 2.45A ) 5B8C (X-ray 2.15A ) 5GGR (X-ray 3.30A ) 5GGS (X-ray 2.00A ) 5IUS (X-ray 2.89A ) 5JXE (X-ray 2.90A ) 5WT9 (X-ray 2.40A ) 6HIG (X-ray 2.20A ) 6J14 (X-ray 1.40A ) 6J15 (X-ray 2.60A ) 6JBT (X-ray 2.47A ) 6JJP (X-ray 2.90A ) 6K0Y (X-ray 1.70A ) 6R5G (NMR - ) 6ROY (X-ray 2.10A ) 6ROZ (X-ray 2.89A ) 6UMT (X-ray 1.99A ) 6UMU (X-ray 1.18A ) 6UMV (X-ray 1.42A ) 6XKR (X-ray 2.59A ) 7BXA (X-ray 3.32A ) 7CGW (X-ray 3.20A ) 7CU5 (X-ray 2.81A ) 7E9B (X-ray 1.78A ) 7VUX (X-ray 1.64A ) 7WSL (X-ray 1.53A ) 7WVM (X-ray 3.40A ) |
| DBSNP | rs2227982 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:30487606}; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
| click here to return to the previous page | |