| Gene Information | |
|---|---|
| Gene Name | PDE8A |
| Organism | Homo sapiens (Human) |
| Gene Length | 829 |
| Protein Names | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53) |
| Target Name | cyclic nucleotide phosphodiesterase |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000073417 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60658 |
| Gene Card | PDE8A |
| Uniprot ID | O60658 |
| Pfam | PF00989; PF00233 |
| In ASD | no |
| Allosteric Prediction | yes (0.596288768) |
| Ortholog in Animals | Alpaca_ PDE8A ( ortholog_one2one ) Dog_ PDE8A ( ortholog_one2one ) GuineaPig_ PDE8A ( ortholog_one2one ) Macaque_ PDE8A ( ortholog_one2one ) Mouse_ Pde8a ( ortholog_one2one ) Pig_ PDE8A ( ortholog_one2one ) Rat_ Pde8a ( ortholog_one2one ) Rabbit_ PDE8A ( ortholog_one2one ) |
| Ohnologs | PDE8B, PDE7A |
| Paralogs | PDE4A, PDE4D, PDE4B, PDE6A, PDE2A, PDE6C, PDE8B, PDE1B, PDE9A, PDE10A, PDE1A, PDE7A, PDE3B, PDE1C, PDE11A, PDE5A, PDE3A, PDE7B, PDE6B, PDE4C |
| Tissue | NA |
| Tissue Specificity | Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3ECM (X-ray 1.90A ) 3ECN (X-ray 2.10A ) 7CWA (X-ray 2.80A ) 7CWF (X-ray 2.80A ) 7CWG (X-ray 2.80A ) |
| DBSNP | rs17855018 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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