| Gene Information | |
|---|---|
| Gene Name | CLIC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 241 |
| Protein Names | Chloride intracellular channel protein 1 (Chloride channel ABP) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chloride ion channel protein) (hRNCC) |
| Target Name | chloride intracellular channel protein 1 |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000206394 ) >4290 ( ENSG00000213719 ) 3 ( ENSG00000223639 ) 3 ( ENSG00000226248 ) 3 ( ENSG00000226417 ) 3 ( ENSG00000226651 ) 3 ( ENSG00000230685 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O00299 |
| Gene Card | CLIC1 |
| Uniprot ID | O00299 |
| Pfam | PF13409 |
| In ASD | no |
| Allosteric Prediction | yes (0.53370443) |
| Ortholog in Animals | Alpaca_ CLIC1 ( ortholog_one2one ) Dog_ CLIC1 ( ortholog_one2many ) GuineaPig_ CLIC1 ( ortholog_one2one ) Macaque_ CLIC1 ( ortholog_one2one ) Mouse_ Clic1 ( ortholog_one2one ) Rat_ Clic1 ( ortholog_one2one ) Rabbit_ CLIC1 ( ortholog_one2one ) |
| Ohnologs | CLIC3 |
| Paralogs | CLIC2, GSTZ1, GSTO2, GDAP1L1, CLIC3, GSTT4, CLIC4, GSTT2, GSTT2B, EEF1G, GDAP1, GSTO1, CLIC6, CLIC5 |
| Tissue | NA |
| Tissue Specificity | Expression is prominent in heart, placenta, liver, kidney and pancreas. {ECO:0000269|PubMed:10793131}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1K0M (X-ray 1.40A ) 1K0N (X-ray 1.80A ) 1K0O (X-ray 1.75A ) 1RK4 (X-ray 1.79A ) 3O3T (X-ray 1.70A ) 3P8W (X-ray 2.00A ) 3P90 (X-ray 2.30A ) 3QR6 (X-ray 1.78A ) 3SWL (X-ray 2.35A ) 3TGZ (X-ray 2.30A ) 3UVH (X-ray 1.84A ) 4IQA (X-ray 2.49A ) 4JZQ (X-ray 1.35A ) 4K0G (X-ray 1.40A ) 4K0N (X-ray 1.25A ) 7F8R (X-ray 2.51A ) 7FBQ (X-ray 1.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12681486, ECO:0000269|PubMed:9139710}. Nucleus membrane {ECO:0000269|PubMed:9139710}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:12681486, ECO:0000269|PubMed:9139710, ECO:0000305|PubMed:11978800, ECO:0000305|PubMed:14613939}. Cell membrane {ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:14613939, ECO:0000305|PubMed:11978800}; Single-pass membrane protein {ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:14613939}. Note=Mostly in the nucleus including in the nuclear membrane (PubMed:9139710, PubMed:12681486). Small amount in the cytoplasm and the plasma membrane (PubMed:9139710). Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (PubMed:11940526, PubMed:11551966, PubMed:14613939). {ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:12681486, ECO:0000269|PubMed:14613939, ECO:0000269|PubMed:9139710}. |
| Mouse PG classification | NA |
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