| Gene Information | |
|---|---|
| Gene Name | ITPR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2701 |
| Protein Names | Inositol 1,4,5-trisphosphate receptor type 2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor) |
| Target Name | ip3 receptor isoform 2 |
| Target Type | Literature-reported target |
| Gene Age | 680 ( ENSG00000123104 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | NA |
| Gene Card | ITPR2 |
| Uniprot ID | Q14571 |
| Pfam | PF08709; PF00520; PF02815; PF08454; PF01365 |
| In ASD | no |
| Allosteric Prediction | yes (1.249420674) |
| Ortholog in Animals | Alpaca_ ITPR2 ( ortholog_one2one ) Dog_ ITPR2 ( ortholog_one2one ) GuineaPig_ ITPR2 ( ortholog_one2one ) Macaque_ ITPR2 ( ortholog_one2one ) Mouse_ Itpr2 ( ortholog_one2one ) Pig_ ITPR2 ( ortholog_one2one ) Rat_ Itpr2 ( ortholog_one2one ) Rabbit_ ITPR2 ( ortholog_one2one ) |
| Ohnologs | ITPR3, ITPR1 |
| Paralogs | RYR2, ITPR3, RYR1, ITPR1, RYR3 |
| Tissue | NA |
| Tissue Specificity | Isoform Short is found in skeletal muscle and heart. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2230384 rs2230373 rs2230382 rs786204832 |
| Subcellular location [CC] | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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