| Gene Information | |
|---|---|
| Gene Name | VAPA |
| Organism | Homo sapiens (Human) |
| Gene Length | 249 |
| Protein Names | Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000101558 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9P0L0 |
| Gene Card | VAPA |
| Uniprot ID | Q9P0L0 |
| Pfam | PF00635 |
| In ASD | no |
| Allosteric Prediction | no (-0.521510918) |
| Ortholog in Animals | Alpaca_ VAPA ( ortholog_one2one ) Dog_ VAPA ( ortholog_one2one ) GuineaPig_ VAPA ( ortholog_one2one ) Macaque_ VAPA ( ortholog_one2one ) Mouse_ Vapa ( ortholog_one2one ) Pig_ VAPA ( ortholog_one2one ) Rat_ Mospd4 ( ortholog_one2many ) Rat_ Vapa ( ortholog_one2many ) |
| Ohnologs | VAPB |
| Paralogs | VAPB |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001240(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2RR3 (NMR - ) 6TQR (X-ray 1.85A ) |
| DBSNP | rs1044163 rs1127666 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10523508, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:25447204, ECO:0000269|PubMed:30741634}; Single-pass type IV membrane protein {ECO:0000269|PubMed:10523508, ECO:0000269|PubMed:19289470}. Cell membrane {ECO:0000269|PubMed:25447204}; Single-pass type IV membrane protein {ECO:0000305}. Cell junction, tight junction {ECO:0000269|PubMed:10523508}. Nucleus membrane {ECO:0000250|UniProtKB:Q9Z270}. Note=Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells. {ECO:0000269|PubMed:10523508}. |
| Mouse PG classification | NA |
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