| Gene Information | |
|---|---|
| Gene Name | PTP4A3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 173 |
| Protein Names | Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (PRL-R) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) |
| Target Name | protein tyrosine phosphatase iva 3 |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000184489 ) 3 ( ENSG00000275575 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O75365 |
| Gene Card | PTP4A3 |
| Uniprot ID | O75365 |
| Pfam | PF00102 |
| In ASD | yes |
| Allosteric Prediction | yes (0.419265344) |
| Ortholog in Animals | Alpaca_ PTP4A3 ( ortholog_one2one ) Dog_ PTP4A3 ( ortholog_one2one ) GuineaPig_ PTP4A3 ( ortholog_one2one ) Macaque_ PTP4A3 ( ortholog_one2one ) Mouse_ Ptp4a3 ( ortholog_one2one ) Pig_ PTP4A3 ( ortholog_one2one ) Rat_ Ptp4a3 ( ortholog_one2one ) Rabbit_ PTP4A3 ( ortholog_one2one ) |
| Ohnologs | PTP4A1, PTP4A2 |
| Paralogs | CDC14A, CDC14B, CDC14C, PTP4A1, CDKN3, PTPDC1, PTP4A2, PALD1 |
| Tissue | NA |
| Tissue Specificity | Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis. {ECO:0000269|PubMed:11355880}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1R6H (NMR - ) 1V3A (NMR - ) 2MBC (NMR - ) 5TSR (X-ray 3.19A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12782572}. Early endosome {ECO:0000269|PubMed:12782572}. |
| Mouse PG classification | NA |
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