| Gene Information | |
|---|---|
| Gene Name | MAPKAPK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 400 |
| Protein Names | MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) |
| Target Name | map kinase-activated protein kinase 2 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000162889 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P49137 |
| Gene Card | MAPKAPK2 |
| Uniprot ID | P49137 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (1.237321505) |
| Ortholog in Animals | Alpaca_ MAPKAPK2 ( ortholog_one2one ) Dog_ MAPKAPK2 ( ortholog_one2one ) GuineaPig_ MAPKAPK2 ( ortholog_one2one ) Macaque_ MAPKAPK2 ( ortholog_one2one ) Mouse_ Mapkapk2 ( ortholog_one2one ) Pig_ MAPKAPK2 ( ortholog_one2one ) Rat_ Mapkapk2 ( ortholog_one2one ) Rabbit_ MAPKAPK2 ( ortholog_one2one ) |
| Ohnologs | MAPKAPK3 |
| Paralogs | MAPKAPK3, MAPKAPK5, MKNK1, MKNK2, CAMK4, DCX |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues examined. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.023529(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1KWP (X-ray 2.80A ) 1NXK (X-ray 2.70A ) 1NY3 (X-ray 3.00A ) 2JBO (X-ray 3.10A ) 2JBP (X-ray 3.31A ) 2OKR (X-ray 2.00A ) 2ONL (X-ray 4.00A ) 2OZA (X-ray 2.70A ) 2P3G (X-ray 3.80A ) 2PZY (X-ray 2.90A ) 3A2C (X-ray 2.90A ) 3FPM (X-ray 3.30A ) 3FYJ (X-ray 3.80A ) 3FYK (X-ray 3.50A ) 3GOK (X-ray 3.20A ) 3KA0 (X-ray 2.90A ) 3KC3 (X-ray 2.90A ) 3KGA (X-ray 2.55A ) 3M2W (X-ray 2.41A ) 3M42 (X-ray 2.68A ) 3R2B (X-ray 2.90A ) 3R2Y (X-ray 3.00A ) 3R30 (X-ray 3.20A ) 3WI6 (X-ray 2.99A ) 4TYH (X-ray 3.00A ) 6T8X (X-ray 2.81A ) 6TCA (X-ray 3.70A ) 7NRY (X-ray 3.80A ) |
| DBSNP | rs35671930 rs55894011 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20932473}. Nucleus {ECO:0000269|PubMed:20932473}. Note=Phosphorylation and subsequent activation releases the autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm. |
| Mouse PG classification | NA |
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