| Gene Information | |
|---|---|
| Gene Name | KIRREL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 708 |
| Protein Names | Kin of IRRE-like protein 2 (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000126259 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q6UWL6 |
| Gene Card | KIRREL2 |
| Uniprot ID | Q6UWL6 |
| Pfam | PF08205; PF07679 |
| In ASD | no |
| Allosteric Prediction | no (-0.675120948) |
| Ortholog in Animals | Alpaca_ KIRREL2 ( ortholog_one2one ) Dog_ KIRREL2 ( ortholog_one2one ) GuineaPig_ KIRREL2 ( ortholog_one2one ) Macaque_ KIRREL2 ( ortholog_one2one ) Mouse_ Kirrel2 ( ortholog_one2one ) Pig_ KIRREL2 ( ortholog_one2one ) Rat_ Kirrel2 ( ortholog_one2one ) Rabbit_ KIRREL2 ( ortholog_one2one ) |
| Ohnologs | KIRREL3, KIRREL1 |
| Paralogs | KIRREL3, NPHS1, KIRREL1 |
| Tissue | pancreas |
| Tissue Specificity | Highly expressed in beta-cells of the pancreatic islets. {ECO:0000269|PubMed:12837264}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs446014 rs404299 rs35423326 rs35775934 rs382789 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q7TSU7}; Single-pass type I membrane protein {ECO:0000255}. Note=Localized along the sites of the cell contacts. Colocalizes with E-Cadherin and beta-catenin. {ECO:0000250|UniProtKB:Q7TSU7}. |
| Mouse PG classification | NA |
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