Gene Information
Gene NameDBNL
OrganismHomo sapiens (Human)
Gene Length430
Protein NamesDrebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000136279 )
Evolutionary StageEukaryota
AlphaFoldDBQ9UJU6
Gene CardDBNL
Uniprot IDQ9UJU6
PfamPF00241; PF14604
In ASDno
Allosteric Predictionyes (0.468054119)
Ortholog in AnimalsAlpaca_ DBNL ( ortholog_one2many )
Dog_ DBNL ( ortholog_one2one )
GuineaPig_ DBNL ( ortholog_one2one )
Macaque_ DBNL ( ortholog_one2one )
Mouse_ Dbnl ( ortholog_one2one )
Pig_ DBNL ( ortholog_one2one )
Rat_ Dbnl ( ortholog_one2one )
OhnologsNA
ParalogsHCLS1, COTL1, CTTN, DBN1
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.003164(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1X67  (NMR  -  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q62418}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q62418}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q62418}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q62418}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JHL4}. Synapse {ECO:0000250|UniProtKB:Q62418}. Perikaryon {ECO:0000250|UniProtKB:Q62418}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q62418}. Cell membrane {ECO:0000269|PubMed:14729663};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q62418};
Cytoplasmic side {ECO:0000250|UniProtKB:Q62418}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q62418};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q62418};
Cytoplasmic side {ECO:0000250|UniProtKB:Q62418}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q62418};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q62418};
Cytoplasmic side {ECO:0000250|UniProtKB:Q62418}. Cell projection, podosome {ECO:0000250|UniProtKB:Q62418}. Early endosome {ECO:0000269|PubMed:14729663}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9JHL4}. Postsynaptic density {ECO:0000250|UniProtKB:Q9JHL4}. Note=Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes. {ECO:0000250|UniProtKB:Q62418, ECO:0000250|UniProtKB:Q9JHL4}.
Mouse PG classificationNA
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