Gene Information
Gene NameAP2B1
OrganismHomo sapiens (Human)
Gene Length937
Protein NamesAP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Target NameNA
Target TypeNA
Gene Age680 ( ENSG00000006125 )
Evolutionary StageEukaryota
AlphaFoldDBP63010
Gene CardAP2B1
Uniprot IDP63010
PfamPF01602; PF02883; PF09066
In ASDno
Allosteric Predictionyes (0.608235959)
Ortholog in AnimalsAlpaca_ AP2B1 ( ortholog_one2one )
Alpaca_ AP2B1 ( ortholog_one2many )
Dog_ AP2B1 ( ortholog_one2one )
GuineaPig_ AP2B1 ( ortholog_one2one )
Macaque_ AP2B1 ( ortholog_one2one )
Mouse_ Ap2b1 ( ortholog_one2one )
Pig_ AP2B1 ( ortholog_one2one )
Rabbit_ AP2B1 ( ortholog_one2one )
OhnologsAP1B1, AP4B1
ParalogsAP1B1, AP4B1, AP3B2, AP3B1
TissueNA
Tissue SpecificityExpressed in the brain (at protein level). {ECO:0000269|PubMed:23676497}.
Pharmacological Animal Models0.154324(Chimpanzee);0.119705(Mouse);NULL(Rat);0.048000(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1E42  (X-ray  1.70A  )  2G30  (X-ray  1.60A  )  2IV8  (X-ray  2.80A  )  2IV9  (X-ray  1.90A  )  2JKR  (X-ray  2.98A  )  2JKT  (X-ray  3.40A  )  2VGL  (X-ray  2.59A  )  2XA7  (X-ray  3.10A  )  4UQI  (X-ray  2.79A  )  5M5R  (X-ray  1.76A  )  6QH5  (X-ray  2.56A  )  6QH6  (X-ray  5.00A  )  6QH7  (X-ray  3.40A  )  6URI  (X-ray  3.00A  )  6YAE  (EM  3.90A  )  6YAF  (EM  9.10A  )  6YAH  (EM  10.20A  )  6YAI  (EM  9.20A  )  7OG1  (X-ray  3.25A  )  7OHO  (X-ray  2.88A  )  7OM8  (EM  10.50A  )  7Z5C  (EM  4.16A  ) 
DBSNP NA 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:14530274}. Membrane, coated pit {ECO:0000269|PubMed:14530274};
Peripheral membrane protein {ECO:0000269|PubMed:14530274};
Cytoplasmic side {ECO:0000269|PubMed:14530274}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.
Mouse PG classificationNA
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