| Gene Information | |
|---|---|
| Gene Name | VASN |
| Organism | Homo sapiens (Human) |
| Gene Length | 673 |
| Protein Names | Vasorin (Protein slit-like 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000168140 ) 3 ( ENSG00000274334 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6EMK4 |
| Gene Card | VASN |
| Uniprot ID | Q6EMK4 |
| Pfam | PF00008; PF13855 |
| In ASD | no |
| Allosteric Prediction | no (-0.829489521) |
| Ortholog in Animals | Alpaca_ VASN ( ortholog_one2one ) Dog_ VASN ( ortholog_one2one ) GuineaPig_ VASN ( ortholog_one2one ) Macaque_ VASN ( ortholog_one2one ) Mouse_ Vasn ( ortholog_one2one ) Pig_ VASN ( ortholog_one2one ) Rat_ Vasn ( ortholog_one2one ) Rabbit_ VASN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CD180, RXFP1, TLR8, NRROS, TLR5, TSKU, TLR7, TLR10, RXFP2, TLR6, LRRC3B, IGFALS, TLR3, TLR2, TLR4, LRRC17, LRRC32, LRRC53, TLR1, LRRC3C, LRRC3, LRIT2 |
| Tissue | NA |
| Tissue Specificity | Expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. Within the aorta, the strongest expression is found in the tunica media of the proximal ascending aorta, the descending thoracic aorta, the abdominal aorta and the coronary arteries. Within the kidney, expression is found in the interstitial cells. {ECO:0000269|PubMed:15247411}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.004323(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3810818 |
| Subcellular location [CC] | Membrane {ECO:0000305|PubMed:15247411}; Single-pass type I membrane protein {ECO:0000305|PubMed:15247411}. Secreted {ECO:0000269|PubMed:15247411}. |
| Mouse PG classification | NA |
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