| Gene Information | |
|---|---|
| Gene Name | FNIP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1114 |
| Protein Names | Folliculin-interacting protein 2 (FNIP1-like protein) (O6-methylguanine-induced apoptosis 1 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000052795 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9P278 |
| Gene Card | FNIP2 |
| Uniprot ID | Q9P278 |
| Pfam | PF14638; PF14637; PF14636 |
| In ASD | no |
| Allosteric Prediction | no (-1.314734267) |
| Ortholog in Animals | Alpaca_ FNIP2 ( ortholog_one2one ) Dog_ FNIP2 ( ortholog_one2one ) GuineaPig_ FNIP2 ( ortholog_one2one ) Macaque_ FNIP2 ( ortholog_one2one ) Mouse_ Fnip2 ( ortholog_one2one ) Pig_ FNIP2 ( ortholog_one2one ) Rat_ Fnip2 ( ortholog_one2one ) Rabbit_ FNIP2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FNIP1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat, liver, heart, placenta and pancreas (PubMed:18403135, PubMed:18663353, PubMed:27353360). Moderately expressed in the lung, small intestine, kidney and brain. Lower levels detected in renal cell carcinoma than in normal kidney tissue (PubMed:18403135). Higher levels detected in oncocytoma tumors than in normal kidney. Higher levels detected in renal cell carcinoma tumors than in normal kidney tissue (PubMed:27353360). {ECO:0000269|PubMed:18403135, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:27353360}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002101(Rat);0.022222(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6NZD (EM 3.60A ) 6ULG (EM 3.31A ) 7LSW (X-ray 3.05A ) 7LT6 (X-ray 1.80A ) |
| DBSNP | rs2276938 |
| Subcellular location [CC] | Lysosome membrane {ECO:0000305|PubMed:31672913}. Cytoplasm {ECO:0000269|PubMed:18403135, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:19137017}. Note=Colocalizes with FLCN in the cytoplasm. {ECO:0000269|PubMed:18403135, ECO:0000269|PubMed:18663353}. |
| Mouse PG classification | NA |
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