| Gene Information | |
|---|---|
| Gene Name | CD22 |
| Organism | Homo sapiens (Human) |
| Gene Length | 847 |
| Protein Names | B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) |
| Target Name | b-cell receptor cd22 |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000012124 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P20273 |
| Gene Card | CD22 |
| Uniprot ID | P20273 |
| Pfam | PF08205; PF13895 |
| In ASD | no |
| Allosteric Prediction | yes (0.411934786) |
| Ortholog in Animals | Alpaca_ CD22 ( ortholog_one2one ) Dog_ MAG ( ortholog_one2one ) GuineaPig_ CD22 ( ortholog_one2one ) Macaque_ CD22 ( ortholog_one2one ) Mouse_ Cd22 ( ortholog_one2one ) Pig_ CD22 ( ortholog_one2one ) Rat_ Cd22 ( ortholog_one2one ) Rabbit_ CD22 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SIGLEC5, TMEM25, SIGLEC1, SIGLEC15, SIGLEC7, SIGLEC11, SIGLEC8, CD33, SIGLEC9, SIGLEC12, SIGLEC16, SIGLEC10, SIGLEC14, SIGLEC6, SIGLECL1, MAG |
| Tissue | spleen, ovary |
| Tissue Specificity | B-lymphocytes. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5VKJ (X-ray 2.12A ) 5VKM (X-ray 2.20A ) 5VL3 (X-ray 3.10A ) 7O52 (X-ray 2.41A ) |
| DBSNP | rs201453271 rs554866571 rs752024645 rs35715143 rs1058407 rs17719289 rs749980313 rs10406069 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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