| Gene Information | |
|---|---|
| Gene Name | CTSE |
| Organism | Homo sapiens (Human) |
| Gene Length | 396 |
| Protein Names | Cathepsin E (EC 3.4.23.34) [Cleaved into: Cathepsin E form I; Cathepsin E form II] |
| Target Name | cathepsin e |
| Target Type | Literature-reported target |
| Gene Age | 454 ( ENSG00000196188 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P14091 |
| Gene Card | CTSE |
| Uniprot ID | P14091 |
| Pfam | PF07966; PF00026 |
| In ASD | no |
| Allosteric Prediction | yes (0.209941394) |
| Ortholog in Animals | Alpaca_ CTSE ( ortholog_one2one ) Dog_ CTSE ( ortholog_one2one ) GuineaPig_ CTSE ( ortholog_one2one ) Macaque_ CTSE ( ortholog_one2one ) Mouse_ Ctse ( ortholog_one2one ) Rat_ Ctse ( ortholog_one2one ) Rabbit_ CTSE ( ortholog_one2one ) |
| Ohnologs | PGC, CTSD |
| Paralogs | PGC, BACE2, REN, BACE1, NAPSA, CTSD, PGA5, PGA4, PGA3 |
| Tissue | stomach, small.intestine |
| Tissue Specificity | Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes. {ECO:0000269|PubMed:11322887, ECO:0000269|PubMed:1370478, ECO:0000269|PubMed:8765029}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1TZS (X-ray 2.35A ) |
| DBSNP | rs57621203 rs6503 |
| Subcellular location [CC] | Endosome {ECO:0000269|PubMed:7983070}. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome. |
| Mouse PG classification | NA |
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