| Gene Information | |
|---|---|
| Gene Name | PACSIN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 486 |
| Protein Names | Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000100266 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UNF0 |
| Gene Card | PACSIN2 |
| Uniprot ID | Q9UNF0 |
| Pfam | PF00611; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (0.184732135) |
| Ortholog in Animals | Alpaca_ PACSIN2 ( ortholog_one2one ) Dog_ PACSIN2 ( ortholog_one2one ) GuineaPig_ PACSIN2 ( ortholog_one2one ) Mouse_ Pacsin2 ( ortholog_one2one ) Pig_ PACSIN2 ( ortholog_one2one ) Rat_ Pacsin2 ( ortholog_one2one ) Rabbit_ PACSIN2 ( ortholog_one2one ) |
| Ohnologs | PACSIN1, PACSIN3 |
| Paralogs | PACSIN1, PACSIN3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:11082044, ECO:0000269|PubMed:11179684}. |
| Pharmacological Animal Models | 0.051455(Chimpanzee);0.031085(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3ABH (X-ray 2.00A ) 3ACO (X-ray 2.70A ) 3HAJ (X-ray 2.78A ) 3Q0K (X-ray 2.60A ) |
| DBSNP | rs35383004 rs2746984 rs1062913 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection {ECO:0000269|PubMed:31242077}. Membrane, caveola {ECO:0000269|PubMed:22323287}. Note=Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1. |
| Mouse PG classification | NA |
| click here to return to the previous page | |