| Gene Information | |
|---|---|
| Gene Name | CDK14 |
| Organism | Homo sapiens (Human) |
| Gene Length | 469 |
| Protein Names | Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000058091 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O94921 |
| Gene Card | CDK14 |
| Uniprot ID | O94921 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.415225738) |
| Ortholog in Animals | Alpaca_ CDK14 ( ortholog_one2one ) Dog_ CDK14 ( ortholog_one2one ) GuineaPig_ CDK14 ( ortholog_one2one ) Macaque_ CDK14 ( ortholog_one2one ) Mouse_ Cdk14 ( ortholog_one2one ) Pig_ CDK14 ( ortholog_one2one ) Rat_ Cdk14 ( ortholog_one2one ) |
| Ohnologs | CDK15 |
| Paralogs | CDKL2, CDK5, CDKL3, CDK7, CDK3, CDK1, CDKL1, CDK19, CDKL5, CDK6, CDK16, CDK15, CDK4, CDKL4, CDK2, CDK20, CDK9, CDK12, CDK8, CDK10, CDK11B, CDK11A, CDK13, CDK18, CDK17, PRPF4B |
| Tissue | amygdala, brain, brain.meninx, caudate.nucleus, hippocampus, middle.frontal.gyrus, middle.temporal.gyrus, occipital.cortex, occipital.lobe, parietal.lobe |
| Tissue Specificity | Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected. {ECO:0000269|PubMed:11313143}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs773301216 rs35643773 |
| Subcellular location [CC] | Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY. |
| Mouse PG classification | NA |
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